Cyclin D1的意思|示意

Cyclin D1 which functions as a mitogenic sensor and allosteric activator of CDK4/6, is one of the more frequently altered cell cycle regulators in cancers.

细胞周期蛋白D1作为一个能促进有丝分裂和CDK4的变构激活剂，是癌症中较频繁变化的细胞周期调节子。

Conclusion Ribozyme targeting cyclin Dl may effectively inhibit cyclin D1 expression and activation in the HSC T6 cell line.

结论载体表达的特异性核酶能有效地抑制HSC的细胞周期蛋白d1的表达和激活。

METHODS: Method of multiplex polymerase chain reaction (PCR) was adopted. Cyclin D1 gene and P16 gene were amplified in the same tube, using extracted genome DNA as template.

方法：采用多重聚合酶链反应方法，以提取的基因组d NA为模板，在同一反应管中同时扩增细胞周期素d 1基因和P 16基因。

CONCLUSION: the high amplification of Cyclin D1 and the high deletion of P16 gene is closely related to the high activity of proliferation of lung cancer.

结论：细胞周期素d1的扩增和P 16的缺失与肺癌细胞的高增殖活性密切相关。

AIM: to construct the recombinant expression vector and to obtain large amount of mouse Cyclin D1 protein fused to PTD.

目的：构建融合重组表达载体并对其进行诱导表达和蛋白纯化以获得大量重组融合蛋白。

Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle.

周期素d 1编码一种全酶的调节亚单位，该酶利用蛋白磷酸化灭活视网膜母细胞瘤蛋白，通过细胞周期G 1 - S期促进肿瘤进展恶化。