acyl fluoride的意思|示意

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Acyl fluoride, also known as acyl chlorides and acid chlorides, are organic compounds containing the functional group R–COF, with R representing an organic radical. They are reactive organic derivatives of the corresponding carboxylic acids. The critical reaction of acyl fluorides is the replacement of the fluoride ion with nucleophilic species such as hydroxide or amines.

Acyl fluorides are commonly used in organic synthesis due to their reactivity towards other molecules. For example, acyl fluorides are used to prepare amides by reacting with amines and esters by reacting with alcohols. They are also used to introduce acyl groups into molecules through substitution reactions. Moreover, acyl fluorides can be used to prepare anhydrides by reacting with alcohols, as well as to introduce new fluorides in organic molecules.

Acyl fluorides must be handled with caution, as they are irritants and are corrosive to metals and tissue. They should be stored in glass containers, in a cool, dry place, away from light and moisture. Furthermore, protective clothing and eye protection should be worn when handling them.