any major change的意思|示意

Any major change to established practices will have an up-front cost.

任何对已建立的实践的主要变更将拥有预先成本。

This would be a major change to programmer expectations about local variables, especially in the absence of any special declaration that this is one of those weird new long-lived local variables.

这是对程序员关于局部变量的预期的重大变更，具体来讲，缺少了任何将此变量声明为奇怪的、新的耐久局部变量的特殊声明。

Here also the major initiatives that are the basis of any change and that will bring major changes to your life.

主要行动同时也是任何变化的基础，会给你的生活带来最主要的变化。

One respondent noted, "The only change is that I now discuss any major capital acquisitions with Warren."

一位受访者说：“唯一的变化是现在我会跟沃伦商讨每一笔重大收购。”

They appreciated the tricky point that any major change can be stressful.

他们领会到这一难办之处，即任何大的改变都是充满压力的。

Were you able to find any direct correlation between this and some event or major change in human life that occurred around the same time?

你是否能够找到这段时间内和此直接相关的一些事件或者人类生活的大的变化？